Pediatric Phase I/II study
INFORM2 VolVin
A pediatric study of volasertib in combination with vinorelbine.
Phase I/II
About the study
Volasertib with vinorelbine
Led by Hopp Children’s Cancer Center Heidelberg (KiTZ)
Study design
A multinational, multi-arm basket trial evaluating a combination of volasertib and vinorelbine in children with selected relapsed or refractory malignancies. The study brings multiple tumor types into one protocol and uses molecular information to help evaluate which patients may be most likely to benefit.
Clinical focus
Rhabdomyosarcoma, Ewing sarcoma, medulloblastoma, neuroblastoma and diffuse midline glioma, including DIPG.
What the study aims to learn
Determine tolerable dosing for the combination, assess early signals of antitumor activity, and explore the relationship between molecular biomarkers and outcomes.
Trial leadership · Cornelis van Tilburg, MD, PhD
Explore our pipeline →