Volasertib Trial
Ein Herz für Kinder INFORM2 VolVin Status: Start-Up Phase
An exploratory multinational, multi-arm Phase 1/2 basket trial, led by Hopp Children’s Cancer Center Heidelberg (KiTZ), evaluating volasertib in combination with vinorelbine.
-
Rhabdomyosarcoma, Ewing sarcoma, medulloblatoma, neuroblastoma, and DMG-DIPG.
-
Seamless Phase 1/2, four trial arms (rhabdomyosarcoma, Ewing sarcoma, medulloblastoma, neuroblastoma, DMG-DIPG), biomarker- driven enrollment.
-
Define safe dosing, assess drug efficacy, and evaluate molecular biomarkers.
-
~110 children across multiple cancer types and centers around the world
-
Pediatric Oncologist. Head Clinical Trial Unit, Group Leader at Hopp Children’s Cancer Center - Heidelberg (KITZ)